LymphedemaV1, Main, Exploration, bibRecord, 004C18

Proliferative responses of Brugia malayi TPX-1 and its epitopic peptide(29-43) in an endemic population of human lymphatic filariasis.

Identifieur interne : 004C18 ( Main/Exploration ); précédent : 004C17; suivant : 004C19

Proliferative responses of Brugia malayi TPX-1 and its epitopic peptide(29-43) in an endemic population of human lymphatic filariasis.

Auteurs : Jayaprakasam Madhumathi [Inde] ; Gandhirajan Anugraha ; Prabhu Rajaiah Prince ; Dhinakar Pradiba ; Perumal Kaliraj

Source :

Microbes and infection [ 1769-714X ] ; 2011.

RBID : pubmed:21288496

Descripteurs français

KwdFr :
- Animaux, Antigènes d'helminthe (immunologie), Brugia malayi (immunologie), Déterminants antigéniques des lymphocytes T (immunologie), Femelle, Filariose lymphatique (immunologie), Filariose lymphatique (parasitologie), Humains, Peroxirédoxines (immunologie), Souris, Souris de lignée BALB C.
MESH :
- immunologie : Antigènes d'helminthe, Brugia malayi, Déterminants antigéniques des lymphocytes T, Filariose lymphatique, Peroxirédoxines.
- parasitologie : Filariose lymphatique.
- Animaux, Femelle, Humains, Souris, Souris de lignée BALB C.

English descriptors

KwdEn :
- Animals, Antigens, Helminth (immunology), Brugia malayi (immunology), Elephantiasis, Filarial (immunology), Elephantiasis, Filarial (parasitology), Epitopes, T-Lymphocyte (immunology), Female, Humans, Mice, Mice, Inbred BALB C, Peroxiredoxins (immunology).
MESH :
- chemical , immunology : Antigens, Helminth, Epitopes, T-Lymphocyte, Peroxiredoxins.
- immunology : Brugia malayi, Elephantiasis, Filarial.
- parasitology : Elephantiasis, Filarial.
- Animals, Female, Humans, Mice, Mice, Inbred BALB C.

Abstract

Although the antioxidant thioredoxin peroxidase (TPX) is a putative target exploited in vaccine studies of lymphatic filariasis, the high sequence homology with host peroxiredoxins remains a great concern. The emergence of immunomics offers a powerful tool for novel vaccine design. Further, due to the cellular hypo-response in filariasis, analysis of T epitope repertoire becomes imperative in disease control. Here, we report the cellular responses of filarial TPX-1 and the identification of T epitope (29-43) in the host non-homologous region. The strong proliferative responses induced by the peptide mimetic in mice splenocytes and human PBMC's prove the existence of T epitope recognized in endemic population.

DOI: 10.1016/j.micinf.2011.01.008
PubMed: 21288496

Affiliations:

Inde

Le document en format XML

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<front><div type="abstract" xml:lang="en">Although the antioxidant thioredoxin peroxidase (TPX) is a putative target exploited in vaccine studies of lymphatic filariasis, the high sequence homology with host peroxiredoxins remains a great concern. The emergence of immunomics offers a powerful tool for novel vaccine design. Further, due to the cellular hypo-response in filariasis, analysis of T epitope repertoire becomes imperative in disease control. Here, we report the cellular responses of filarial TPX-1 and the identification of T epitope (29-43) in the host non-homologous region. The strong proliferative responses induced by the peptide mimetic in mice splenocytes and human PBMC's prove the existence of T epitope recognized in endemic population.</div>
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Proliferative responses of Brugia malayi TPX-1 and its epitopic peptide(29-43) in an endemic population of human lymphatic filariasis.

Proliferative responses of Brugia malayi TPX-1 and its epitopic peptide(29-43) in an endemic population of human lymphatic filariasis.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur le lymphœdème
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